Article
Helicobacter pylori versus the host: remodeling of the bacterial outer membrane is required for survival in the gastric mucosa.
PLoS pathogens - 1 Dec 2011
Cullen Thomas W, Giles David K, Wolf Lindsey N, Ecobichon Chantal, Boneca Ivo G, Trent M Stephen
Abstract excerpt
Modification of bacterial surface structures, such as the lipid A portion of lipopolysaccharide (LPS), is used by many pathogenic bacteria to help evade the host innate immune response. Helicobacter pylori, a gram-negative bacterium capable of chronic colonization of the human stomach, modifies its lipid A by removal of phosphate groups from the 1- and 4'-positions of the lipid A backbone. In this study, we...
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