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Interleukin-1B gene promoter variants are associated with an increased risk of gastric cancer in a Chinese population.

Cancer letters - 25 Nov 2004

Yang Jie, Hu Zhibin, Xu Yaochu, Shen Jin, Niu Juyin, Hu Xu, Guo Jiantao, Wei Qingyi, Wang Xinru, Shen Hongbing

Abstract excerpt

Studies suggest that IL-1beta (encoded by IL-1B gene) is a pro-inflammatory cytokine and potent inhibitor of gastric acid secretion, which is proposed as a key determinant in gastric carcinogenesis. Two potentially functional polymorphisms (C-31T and T-511C) in the IL-1B promoter were suggested to be correlated with alteration of Helicobacter pylori infection and IL-1beta expression and therefore may be...

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PMID: 15488638
DOI: 10.1016/j.canlet.2004.07.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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