Article
Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese.
Journal of gastroenterology - 1 Oct 2001
Kato S, Onda M, Yamada S, Matsuda N, Tokunaga A, Matsukura N
Abstract excerpt
BACKGROUND: Helicobacter pylori infection is associated not only with gastroduodenal ulcers but with the development of gastric cancer. Interleukin-1 beta (IL-1 beta) is a potent inhibitor of gastric secretion. The -31 C-to-T base transition in the intron of this gene has been reported to be involved in carcinogenic changes within the stomach, especially in H. pylori-infected individuals. METHODS: In this study,...
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