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Article

Medulloblastoma: a problem of developmental biology.

Cancer cell - 1 Jul 2002

Rubin Joshua B, Rowitch David H

Abstract excerpt

The identification of SUFU mutations in desmoplastic medulloblastoma provides new insights into vertebrate Hedgehog signaling and brain tumor formation.

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12150819
DOI: 10.1016/s1535-6108(02)00090-9

Genes

SUFU

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Medulloblastoma: a problem of developmental biology.PMID 12150819Read ↗

Medulloblastoma in the age of molecular subgroups: a reviewSemantic proximity Read ↗

High Frequency of Germline SUFU Mutations in Children With Desmoplastic/Nodular Medulloblastoma Younger Than 3 Years of AgeSemantic proximity Read ↗

Deconstructing Sonic Hedgehog Medulloblastoma: Molecular Subtypes, Drivers, and BeyondSemantic proximity Read ↗

Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations.Semantic proximity Read ↗

Medulloblastoma can be initiated by deletion of Patched in lineage-restricted progenitors or stem cells.Semantic proximity Read ↗

Role and regulation of human tumor suppressor SUFU in Hedgehog signaling.Semantic proximity Read ↗

Mutations in SUFU predispose to medulloblastoma.Semantic proximity Read ↗

Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models.Semantic proximity Read ↗

No evidence for mutations or altered expression of the Suppressor of Fused gene (SUFU) in primitive neuroectodermal tumours.Semantic proximity Read ↗

Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinctSemantic proximity Read ↗

Molecular Diagnostics in Embryonal Brain TumorsSemantic proximity Read ↗

Misactivation of Hedgehog signaling causes inherited and sporadic cancersSemantic proximity Read ↗

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