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Article

Amino acid modification in the HIV-1 Tat basic domain: insights from molecular dynamics and in vivo functional studies.

Journal of molecular biology - 17 May 2002

Pantano Sergio, Tyagi Mudit, Giacca Mauro, Carloni Paolo

Abstract excerpt

Tat is an essential protein of the human immunodeficiency virus type 1 (HIV-1). It activates transcription by specifically binding a stem-loop element in the viral long terminal repeat through its highly basic arginine-rich domain. Conserved lysine residues at positions 50 and 51 inside this domain have been recently reported to be the targets of post-translational modification by acetylation, and mutation of...

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Source

Identifiers

PMID: 12083521
DOI: 10.1016/s0022-2836(02)00217-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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