Article
Analysis of the influence of subcellular localization of the HIV Rev protein on Rev-dependent gene expression by multi-fluorescence live-cell imaging.
Experimental cell research - 15 Feb 2006
Wolff Horst, Hadian Kamyar, Ziegler Manja, Weierich Claudia, Kramer-Hammerle Susanne, Kleinschmidt Andrea, Erfle Volker, Brack-Werner Ruth
Abstract excerpt
The human immunodeficiency virus Rev protein is a post-transcriptional activator of HIV gene expression. Rev is a nucleocytoplasmic shuttle protein that displays characteristic nuclear/nucleolar subcellular localization in various cell lines. Cytoplasmic localization of Rev occurs under various conditions disrupting Rev function. The goal of this study was to investigate the relationship between localization of...
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