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Article

Oct4 is required for primordial germ cell survival.

EMBO reports - 1 Nov 2004

Kehler James, Tolkunova Elena, Koschorz Birgit, Pesce Maurizio, Gentile Luca, Boiani Michele, Lomelí Hilda, Nagy Andras, McLaughlin K John, Schöler Hans R, Tomilin Alexey

Abstract excerpt

Previous studies have shown that Oct4 has an essential role in maintaining pluripotency of cells of the inner cell mass (ICM) and embryonic stem cells. However, Oct4 null homozygous embryos die around the time of implantation, thus precluding further analysis of gene function during development. We have used the conditional Cre/loxP gene targeting strategy to assess Oct4 function in primordial germ cells (PGCs)....

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Identifiers

PMID: 15486564
DOI: 10.1038/sj.embor.7400279
PMCID: PMC1299174

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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