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In line with our ancestors: Oct-4 and the mammalian germ

7 Dec 1998

Abstract excerpt

The transcription factor Oct-4 is expressed specifically in the totipotent germline cycle of mice. Cells that lose Oct-4 differentiate along different paths to form embryonic and extraembryonic somatic tissue. Oct-4 may maintain the potency of stem and germline cells by preventing all other differentiation pathways. Oct-4 may also regulate the molecular differentiation of cells in the germ lineage as it...

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PMID: 9819561
DOI: 10.1002/(sici)1521-1878(199809)20:9<722::aid-bies5>3.0.co;2-i

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