Article
The pluripotency regulator Oct4: A role in somatic stem cells?
15 Mar 2008
Abstract excerpt
Since its discovery as a critical regulator of pluripotency in embryonic stem (ES) cells and the inner cells mass of the developing blastocyst, the Pou domain-containing transcription factor Oct4 has become a proxy for "stemness" in numerous studies of somatic stem cells as its presence is often taken as evidence of pluripotency in these cells. Recent studies, however, have demonstrated that not only is Oct4...