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Article

Differential expression of the Oct-4 transcription factor during mouse germ cell differentiation

1 Feb 1998

Abstract excerpt

The POU transcription factor Oct-4 is expressed in early mouse embryogenesis and in pluripotent ES and EC stem cell lines. After gastrulation in the embryo, Oct-4 expression is confined to the germline. The present study provides evidence that Oct-4 undergoes downregulation during oogenesis and spermatogenesis, coincident with entry into meiosis. Furthermore, analysis of maturation stages of oocytes showed that...

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PMID: 9507072
DOI: 10.1016/s0925-4773(98)00002-1

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