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Germ cell specification and pluripotency in mammals: a perspective from early embryogenesis

10 Jun 2014

Abstract excerpt

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving rise to the next generation in mammals and many other multicellular organisms. How germ cells acquire this ability has been of considerable interest. In mammals, primordial germ cells (PGCs), the precursors of sperm and oocytes, are specified around the time of gastrulation. PGCs are induced by signals from the...

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PMID: 25298745
DOI: 10.1007/s12522-014-0184-2

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