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Article

Maintaining sufficient nanos is a critical function for polar granule component in the specification of primordial germ cells.

G3 (Bethesda, Md.) - 1 Nov 2012

Deshpande Girish, Spady Emma, Goodhouse Joe, Schedl Paul

Abstract excerpt

Primordial germ cells (PGC) are the precursors of germline stem cells. In Drosophila, PGC specification is thought to require transcriptional quiescence and three genes, polar granule component (pgc), nanos (nos), and germ cell less (gcl) function to downregulate Pol II transcription. While it is not understood how nos or gcl represses transcription, pgc does so by inhibiting the transcription elongation factor b...

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Source

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Identifiers

PMID: 23173091
DOI: 10.1534/g3.112.004192
PMCID: PMC3484670

Genes

PGC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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