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Article

Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.

Molecular and cellular biology - 1 Nov 2004

Kufel Joanna, Bousquet-Antonelli Cecile, Beggs Jean D, Tollervey David

Abstract excerpt

Previous analyses have identified related cytoplasmic Lsm1-7p and nuclear Lsm2-8p complexes. Here we report that mature heat shock and MET mRNAs that are trapped in the nucleus due to a block in mRNA export were strongly stabilized in strains lacking Lsm6p or the nucleus-specific Lsm8p protein but not by the absence of the cytoplasmic Lsm1p. These nucleus-restricted mRNAs remain polyadenylated until their...

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Identifiers

PMID: 15485930
DOI: 10.1128/MCB.24.21.9646-9657.2004
PMCID: PMC522261

Genes

MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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