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Article

The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.

Genetics - 1 Aug 2001

He W, Parker R

Abstract excerpt

A key aspect of understanding eukaryotic gene regulation will be the identification and analysis of proteins that bind mRNAs and control their function. Recently, a complex of seven Lsm proteins and the Pat1p have been shown to interact with yeast mRNAs and promote mRNA decapping. In this study we present several observations to indicate that the LsmI/Pat1 complex has a second distinct function in protecting the...

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Source

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Identifiers

PMID: 11514438
DOI: 10.1093/genetics/158.4.1445
PMCID: PMC1461746

Genes

LSM1
LSM7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.PMID 11514438Read ↗

Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.Semantic proximity Read ↗

lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.Semantic proximity Read ↗

Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7-Pat1 complex.Semantic proximity Read ↗

Yeast Sm-like proteins function in mRNA decapping and decay.Semantic proximity Read ↗

Mutagenic Analysis of the C-Terminal Extension of Lsm1.Semantic proximity Read ↗

Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.Semantic proximity Read ↗

Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.Semantic proximity Read ↗

An mRNA decapping mutant deficient in P body assembly limits mRNA stabilization in response to osmotic stress.Semantic proximity Read ↗

Scavenger decapping activity facilitates 5' to 3' mRNA decay.Semantic proximity Read ↗

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa.Semantic proximity Read ↗

Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.Semantic proximity Read ↗

mRNA decapping in yeast requires dissociation of the cap binding protein, eukaryotic translation initiation factor 4E.Semantic proximity Read ↗

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