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Article

Lsm Proteins are required for normal processing and stability of ribosomal RNAs.

The Journal of biological chemistry - 24 Jan 2003

Kufel Joanna, Allmang Christine, Petfalski Elisabeth, Beggs Jean, Tollervey David

Abstract excerpt

Depletion of any of the essential Lsm proteins, Lsm2-5p or Lsm8p, delayed pre-rRNA processing and led to the accumulation of many aberrant processing intermediates, indicating that an Lsm complex is required to maintain the normally strict order of processing events. In addition, high levels of degradation products derived from both precursors and mature rRNAs accumulated in Lsm-depleted strains. Depletion of the...

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PMID: 12438310
DOI: 10.1074/jbc.M208856200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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