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Article

Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.

Genetics - 1 May 2005

Tharun Sundaresan, Muhlrad Denise, Chowdhury Ashis, Parker Roy

Abstract excerpt

The decapping of eukaryotic mRNAs is a key step in their degradation. The heteroheptameric Lsm1p-7p complex is a general activator of decapping and also functions in protecting the 3' ends of deadenylated mRNAs from a 3'-trimming reaction. Lsm1p is the unique member of the Lsm1p-7p complex, distinguishing that complex from the functionally different Lsm2p-8p complex. To understand the function of Lsm1p, we...

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Source

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Identifiers

PMID: 15716506
DOI: 10.1534/genetics.104.034322
PMCID: PMC1449704

Genes

LSM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutations in the Saccharomyces cerevisiae LSM1 gene that affect mRNA decapping and 3' end protection.PMID 15716506Read ↗

Yeast Sm-like proteins function in mRNA decapping and decay.Semantic proximity Read ↗

Activation of decapping involves binding of the mRNA and facilitation of the post-binding steps by the Lsm1-7-Pat1 complex.Semantic proximity Read ↗

Analysis of Lsm1p and Lsm8p domains in the cellular localization of Lsm complexes in budding yeast.Semantic proximity Read ↗

lsm1 mutations impairing the ability of the Lsm1p-7p-Pat1p complex to preferentially bind to oligoadenylated RNA affect mRNA decay in vivo.Semantic proximity Read ↗

Mutagenic Analysis of the C-Terminal Extension of Lsm1.Semantic proximity Read ↗

The yeast cytoplasmic LsmI/Pat1p complex protects mRNA 3' termini from partial degradation.Semantic proximity Read ↗

Analysis of mutations in the yeast mRNA decapping enzyme.Semantic proximity Read ↗

Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.Semantic proximity Read ↗

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Scavenger decapping activity facilitates 5' to 3' mRNA decay.Semantic proximity Read ↗

Lsm proteins are required for normal processing of pre-tRNAs and their efficient association with La-homologous protein Lhp1p.Semantic proximity Read ↗

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