Article
A complex pathway for 3' processing of the yeast U3 snoRNA.
Nucleic acids research - 1 Dec 2003
Kufel Joanna, Allmang Christine, Verdone Loredana, Beggs Jean, Tollervey David
Abstract excerpt
Mature U3 snoRNA in yeast is generated from the 3'-extended precursors by endonucleolytic cleavage followed by exonucleolytic trimming. These precursors terminate in poly(U) tracts and are normally stabilised by binding of the yeast La homologue, Lhp1p. We report that normal 3' processing of U3 requires the nuclear Lsm proteins. On depletion of any of the five essential proteins, Lsm2-5p or Lsm8p, the normal...
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