Article
Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.
Molecular and cellular biology - 1 Nov 2004
Blanchette Paola, Cheng Chi Ying, Yan Qin, Ketner Gary, Ornelles David A, Dobner Thomas, Conaway Ronald C, Conaway Joan Weliky, Branton Philip E
Abstract excerpt
Small DNA tumor viruses typically encode proteins that either inactivate or degrade p53. Human adenoviruses encode products, including E4orf6 and E1B55K, that do both. Each independently binds to p53 and inhibits its ability to activate gene expression; however, in combination they induce p53 degradation by the ubiquitin pathway. We have shown previously that p53 degradation relies on interactions of E4orf6 with...
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