Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of Adenoviruses

2 Jun 2016

Abstract excerpt

UNLABELLED: E4orf6 proteins from all human adenoviruses form Cullin-based ubiquitin ligase complexes that, in association with E1B55K, target cellular proteins for degradation. While most are assembled with Cul5, a few utilize Cul2. BC-box motifs enable all these E4orf6 proteins to assemble ligase complexes with Elongins B and C. We also identified a Cul2-box motif used for Cul2 selection in all Cul2-based...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Ubiquitin and proteasome pathways
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27252531
DOI: 10.1128/jvi.00420-16

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Using the E4orf6-Based E3 Ubiquitin Ligase as a Tool To Analyze the Evolution of AdenovirusesPMID 27252531Read ↗

The E4orf6/E1B55K E3 Ubiquitin Ligase Complexes of Human Adenoviruses Exhibit Heterogeneity in Composition and Substrate SpecificitySemantic proximity Read ↗

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species DSemantic proximity Read ↗

Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.Semantic proximity Read ↗

E3 Ubiquitin Ligases in Gammaherpesviruses and HIV: A Review of Virus Adaptation and ExploitationSemantic proximity Read ↗

Molecular evolution of human species D adenoviruses.Semantic proximity Read ↗

A comparative review of adenovirus A12 and C5 oncogenesSemantic proximity Read ↗

A novel adenovirus 19K/IX protein promotes infection by preventing proteasomal degradation of tyrosine-ubiquitinated capsid protein pIXSemantic proximity Read ↗

Cullin E3 Ligases and Their Rewiring by Viral FactorsSemantic proximity Read ↗

Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3BSemantic proximity Read ↗

In Silico Intensive Analysis for the E4 Gene Evolution of Human Adenovirus Species D.Semantic proximity Read ↗

Adenovirus E4orf3 Targets Transcriptional Intermediary Factor 1γ for Proteasome-Dependent Degradation during InfectionSemantic proximity Read ↗

Deubiquitinase function of arterivirus papain-like protease 2 suppresses the innate immune response in infected host cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.