Article
Cancer susceptibility of mice with a homozygous deletion in the COOH-terminal domain of the Brca2 gene.
Cancer research - 15 Feb 2002
McAllister Kimberly A, Bennett L Michelle, Houle Chris D, Ward Toni, Malphurs Jason, Collins N Keith, Cachafeiro Carol, Haseman Joseph, Goulding Eugenia H, Bunch Donna, Eddy E Mitch, Davis Barbara J, Wiseman Roger W
Abstract excerpt
Inherited mutations of the human BRCA2 gene confer increased risks for developing breast, ovarian, and several other cancers. Unlike previously described Brca2 knockout mice that display predominantly embryonic lethal phenotypes, we developed mice with a homozygous germ-line deletion of Brca2 exon 27 that exhibit a moderate decrease in perinatal viability and are fertile. We deleted this Brca2 COOH-terminal...
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