Article
NOTCH1 activation compensates BRCA1 deficiency and promotes triple-negative breast cancer formation.
Nature communications - 26 Jun 2020
Miao Kai, Lei Josh Haipeng, Valecha Monica Vishnu, Zhang Aiping, Xu Jun, Wang Lijian, Lyu Xueying, Chen Si, Miao Zhengqiang, Zhang Xin, Su Sek Man, Shao Fangyuan, Rajendran Barani Kumar, Bao Jiaolin, Zeng Jianming, Sun Heng, Chen Ping, Tan Kaeling, Chen Qiang, Wong Koon Ho, Xu Xiaoling, Deng Chu-Xia
Abstract excerpt
BRCA1 mutation carriers have a higher risk of developing triple-negative breast cancer (TNBC), which is a refractory disease due to its non-responsiveness to current clinical targeted therapies. Using the Sleeping Beauty transposon system in Brca1-deficient mice, we identified 169 putative cancer drivers, among which Notch1 is a top candidate for accelerating TNBC by promoting the epithelial-mesenchymal...
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