Article
The cancer connection: BRCA1 and BRCA2 tumor suppression in mice and humans.
Oncogene - 16 Dec 2002
Moynahan Mary Ellen
Abstract excerpt
BRCA1 and BRCA2 mutations are estimated to be responsible for the great majority of familial breast and ovarian cancers. Much progress has been made toward the understanding of the function of these proteins through genetic, biochemical, and structural studies. The embryonic lethality encountered in the knockout mouse initially hindered the development of mouse models aimed at studying tumor suppression. However,...
Topics
- Animals
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Disease Models, Animal
- Fetal Death
- Humans
- Mammary Neoplasms, Experimental
- Mice
- Mutation
- Neoplasms, Experimental
- Tumor Suppressor Protein p53