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Article

Homologous DNA Pairing by Human Recombination Factors Rad51 and Rad54

1 Nov 2002

Abstract excerpt

Human Rad51 (hRad51) and Rad54 proteins are key members of the RAD52 group required for homologous recombination. We show an ability of hRad54 to promote transient separation of the strands in duplex DNA via its ATP hydrolysis-driven DNA supercoiling function. The ATPase, DNA supercoiling, and DNA strand opening activities of hRad54 are greatly stimulated through an interaction with hRad51. Importantly, we...

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Identifiers

PMID: 12205100
DOI: 10.1074/jbc.m208004200

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