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The Essential Functions of Human Rad51 Are Independent of ATP Hydrolysis

1 Oct 1999

Abstract excerpt

Genetic recombination and the repair of double-strand DNA breaks in Saccharomyces cerevisiae require Rad51, a homologue of the Escherichia coli RecA protein. In vitro, Rad51 binds DNA to form an extended nucleoprotein filament and catalyzes the ATP-dependent exchange of DNA between molecules with homologous sequences. Vertebrate Rad51 is essential for cell proliferation. Using site-directed mutagenesis of highly...

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PMID: 10490626
DOI: 10.1128/mcb.19.10.6891

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