Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

doi:10.1161/01.res.72.4.921

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Article

Mutation of N-myristoylation site converts endothelial cell nitric oxide synthase from a membrane to a cytosolic protein.

Circulation research - 1 Apr 1993

Sessa W C, Barber C M, Lynch K R

Abstract excerpt

Endothelial cell nitric oxide synthase (ECNOS) is a membrane-associated enzyme that generates endothelium-derived relaxing factor/nitric oxide (EDRF/NO) from L-arginine. We have suggested, from the cloning of the bovine ECNOS cDNA, that the presence of an N-myristoylation consensus sequence may i...

Topics

Amino Acid Oxidoreductases
Base Sequence
Cell Membrane
Cytosol
Endothelium, Vascular
Molecular Probes
Molecular Sequence Data
Mutation
Nitric Oxide Synthase
Tissue Distribution

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