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Article

Nitric oxide regulates endocytosis by S-nitrosylation of dynamin.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jan 2006

Wang Gaofeng, Moniri Nader H, Ozawa Kentaro, Stamler Jonathan S, Daaka Yehia

Abstract excerpt

The GTPase dynamin regulates endocytic vesicle budding from the plasma membrane, but the molecular mechanisms involved remain incompletely understood. We report that dynamin, which interacts with NO synthase, is S-nitrosylated at a single cysteine residue (C607) after stimulation of the beta(2) adrenergic receptor. S-nitrosylation increases dynamin self-assembly and GTPase activity and facilitates its...

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Source

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Identifiers

PMID: 16432212
DOI: 10.1073/pnas.0508354103
PMCID: PMC1360548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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