Article
Functional avidity directs T-cell fate in autoreactive CD4+ T cells.
Blood - 15 Oct 2005
Mallone Roberto, Kochik Sharon A, Reijonen Helena, Carson Bryan, Ziegler Steven F, Kwok William W, Nepom Gerald T
Abstract excerpt
Major histocompatibility complex class II tetramer staining and activation analysis identified 2 distinct types of antigen-specific CD4+ T cells in the peripheral blood of humans with type 1 (autoimmune) diabetes. T cells with low-avidity recognition of peptide-MHC ligands had low sensitivity to activation and inefficient activation-induced apoptosis. In contrast, high-avidity T cells were highly sensitive to...
Topics
- Adolescent
- Antigen-Presenting Cells
- Antigens
- Apoptosis
- CD4-Positive T-Lymphocytes
- Cells, Cultured
- Clonal Anergy
- Female
- Humans
- Lymphocyte Activation
- Phenotype
- Protein Binding
- Substrate Specificity