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Article

Functional avidity directs T-cell fate in autoreactive CD4+ T cells.

Blood - 15 Oct 2005

Mallone Roberto, Kochik Sharon A, Reijonen Helena, Carson Bryan, Ziegler Steven F, Kwok William W, Nepom Gerald T

Abstract excerpt

Major histocompatibility complex class II tetramer staining and activation analysis identified 2 distinct types of antigen-specific CD4+ T cells in the peripheral blood of humans with type 1 (autoimmune) diabetes. T cells with low-avidity recognition of peptide-MHC ligands had low sensitivity to activation and inefficient activation-induced apoptosis. In contrast, high-avidity T cells were highly sensitive to...

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Identifiers

PMID: 16030184
DOI: 10.1182/blood-2004-12-4848
PMCID: PMC1895305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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