Article
Interleukin-13 gene polymorphisms confer the susceptibility of Japanese populations to Graves' disease.
The Journal of clinical endocrinology and metabolism - 1 Jan 2005
Hiromatsu Yuji, Fukutani Tomoka, Ichimura Michiko, Mukai Tokunori, Kaku Hiroo, Nakayama Hitomi, Miyake Ikuyo, Shoji Shingo, Koda Yoshiro, Bednarczuk Tomasz
Abstract excerpt
Graves' disease (GD) is an autoimmune disorder with genetic predisposition. IL-13 is an important mediator of antiinflammatory immune responses and is expressed in the thyroid and orbit. The aim of the present study was to investigate whether IL-13 gene polymorphisms are associated with the development of GD. IL-13 gene polymorphisms were studied in Japanese GD patients (n = 310) and healthy control subjects...
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