Article
Interleukin-13 gene polymorphisms in patients with Graves' disease.
Clinical endocrinology - 1 Oct 2003
Bednarczuk Tomasz, Placha Grzegorz, Jazdzewski Krystian, Kurylowicz Alina, Kloza Marta, Makowska Urszula, Hiromatsu Yuji, Nauman Janusz
Abstract excerpt
OBJECTIVE: In patients with Graves' disease (GD), an elevation of serum immunoglobulin E (IgE) has been recently reported to be associated with the severity of hyperthyroidism and ophthalmopathy. Interleukin 13 (IL-13) is a major cytokine involved in IgE synthesis and therefore may be a potential candidate gene contributing to the development of GD or influencing the clinical course of the disease. DESIGN: In a...
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