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Article

Interleukin-12B gene polymorphism does not confer susceptibility to Graves' ophthalmopathy in Japanese population.

Endocrine journal - 1 Dec 2006

Hiromatsu Yuji, Fukutani Tomoka, Ichimura Michiko, Mukai Tokunori, Kaku Hiroo, Miyake Ikuyo, Yamada Kentaro

Abstract excerpt

Graves' disease (GD) is an autoimmune disorder with genetic predisposition and frequently associated with Graves' ophthalmopathy (GO). Interleukin 12 (IL-12) is an important mediator of inflammatory immune responses and is expressed in the thyroid and orbit. IL-12B gene, which encodes the p40 subunit of IL-12, is located at chromosome 5q31-33. The aim of the present study was to investigate whether IL-12B gene...

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Identifiers

PMID: 16966828
DOI: 10.1507/endocrj.k06-040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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