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Article

Interleukin (IL)-23 receptor is a major susceptibility gene for Graves' ophthalmopathy: the IL-23/T-helper 17 axis extends to thyroid autoimmunity.

The Journal of clinical endocrinology and metabolism - 1 Mar 2008

Huber Amanda K, Jacobson Eric M, Jazdzewski Krystian, Concepcion Erlinda S, Tomer Yaron

Abstract excerpt

CONTEXT: IL-23 and its receptor (IL-23R) guide T cells toward the T-helper 17 phenotype. IL-23R single nucleotide polymorphisms (SNPs) have been associated with several autoimmune diseases, including Crohn's disease and rheumatoid arthritis. OBJECTIVE: Our objective was to determine whether varia...

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Share to Autoimmunity
Share to Graves Ophthalmopathy
Share to Interleukin-23

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Receptors, Interleukin

Share to STAT4 Transcription Factor

Share to Th1 Cells

Share to Thyroid Gland

Source

Open in PubMed Open full text

Identifiers

PMID: 18073300
DOI: 10.1210/jc.2007-2190
PMCID: PMC2266952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18073300-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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