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Article

BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.

Molecular biology of the cell - 1 Jan 2005

Minoda Aki, Saitoh Shigeaki, Takahashi Kohta, Toda Takashi

Abstract excerpt

Nuclear actin-related proteins play vital roles in transcriptional regulation; however, their biological roles remain elusive. Here, we characterize Alp5, fission yeast homolog of Arp4/BAF53. The temperature-sensitive mutant alp5-1134 contains a single amino acid substitution in the conserved C-terminal domain (S402N) and displays mitotic phenotypes, including chromosome condensation and missegregation. Alp5...

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Identifiers

PMID: 15483052
DOI: 10.1091/mbc.e04-06-0519
PMCID: PMC539175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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BAF53/Arp4 homolog Alp5 in fission yeast is required for histone H4 acetylation, kinetochore-spindle attachment, and gene silencing at centromere.PMID 15483052Read ↗

Actin-related protein Arp4 functions in kinetochore assembly.Semantic proximity Read ↗

Histone H3 lysine 14 acetylation is required for activation of a DNA damage checkpoint in fission yeast.Semantic proximity Read ↗

The V260I mutation in fission yeast alpha-tubulin Atb2 affects microtubule dynamics and EB1-Mal3 localization and activates the Bub1 branch of the spindle checkpoint.Semantic proximity Read ↗

Alp13, an MRG family protein, is a component of fission yeast Clr6 histone deacetylase required for genomic integrity.Semantic proximity Read ↗

Heterocomplex formation by Arp4 and β-actin is involved in the integrity of the Brg1 chromatin remodeling complex.Semantic proximity Read ↗

Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.Semantic proximity Read ↗

MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.Semantic proximity Read ↗

The fission yeast gamma-tubulin complex is required in G(1) phase and is a component of the spindle assembly checkpoint.Semantic proximity Read ↗

H3K9me-independent gene silencing in fission yeast heterochromatin by Clr5 and histone deacetylases.Semantic proximity Read ↗

Regulation of Swi6/HP1-dependent heterochromatin assembly by cooperation of components of the mitogen-activated protein kinase pathway and a histone deacetylase Clr6.Semantic proximity Read ↗

Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint.Semantic proximity Read ↗

Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis.Semantic proximity Read ↗

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