Article
Actin-related protein Arp4 functions in kinetochore assembly.
Nucleic acids research - 1 Jan 2007
Ogiwara Hideaki, Ui Ayako, Kawashima Satoshi, Kugou Kazuto, Onoda Fumitoshi, Iwahashi Hitoshi, Harata Masahiko, Ohta Kunihiro, Enomoto Takemi, Seki Masayuki
Abstract excerpt
The actin-related proteins (Arps) comprise a conserved protein family. Arp4p is found in large multisubunits of the INO80 and SWR1 chromatin remodeling complexes and in the NuA4 histone acetyltransferase complex. Here we show that arp4 (arp4S23A/D159A) temperature-sensitive cells are defective in G2/M phase function. arp4 mutants are sensitive to the microtubule depolymerizing agent benomyl and arrest at G2/M...
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