Article
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis.
Journal of cell science - 1 Feb 2013
Fong Ka-wing, Leung Justin Wai-chung, Li Yujing, Wang Wenqi, Feng Lin, Ma Wenbin, Liu Dan, Songyang Zhou, Chen Junjie
Abstract excerpt
Microtubules (MTs) are the major constituent of the mitotic apparatus. Deregulation of MT dynamics leads to chromosome missegregation, cytokinesis failure and improper inheritance of genetic materials. Here, we describe the identification and characterization of KIAA1383/MTR120 (microtubule regulator 120 kDa) as a novel MT-associated protein. We found that MTR120 localizes to stabilized MTs during interphase and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
