Article
Challenges in the identification of MSH6-associated colorectal cancer: rectal location, less typical histology, and a subset with retained mismatch repair function.
The American journal of surgical pathology - 1 Sept 2011
Klarskov Louise, Holck Susanne, Bernstein Inge, Okkels Henrik, Rambech Eva, Baldetorp Bo, Nilbert Mef
Abstract excerpt
Identification of Lynch syndrome tumors is challenging. This relates particularly to MSH6-associated cases, which show reduced penetrance of colorectal cancer and a higher age at diagnosis. We recorded the clinical and morphologic features of 52 MSH6-associated colorectal cancers in comparison with MLH1/MSH2-mutant tumors and sporadic mismatch repair-deficient cancers. In the MSH6 subset, we confirmed a higher...
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