Article
MSH6 mutations are frequent in hereditary nonpolyposis colorectal cancer families with normal pMSH6 expression as detected by immunohistochemistry.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Oct 2012
Okkels Henrik, Lindorff-Larsen Karen, Thorlasius-Ussing Ole, Vyberg Mogens, Lindebjerg Jan, Sunde Lone, Bernstein Inge, Klarskov Louise, Holck Susanne, Krarup Henrik Bygum
Abstract excerpt
INTRODUCTION: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant condition accounting for 2% to 4% of all colorectal cancer cases worldwide. Families with germ line mutations in 1 of 6 mismatch repair genes are known as Lynch syndrome families. The largest number of mutations has been detected in the mismatch repair genes MLH1 and MSH2, but several mutations in MSH6 have also been...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.