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MSH6 and MUTYH Deficiency Is a Frequent Event in Early-Onset Colorectal Cancer

7 Oct 2010

Abstract excerpt

PURPOSE: Early-onset colorectal cancer (CRC) is suggestive of a hereditary predisposition. Lynch syndrome is the most frequent CRC hereditary cause. The MUTYH gene has also been related to hereditary CRC. A systematic characterization of these two diseases has not been reported previously in this population. EXPERIMENTAL DESIGN: We studied a retrospectively collected series of 140 patients ≤50 years old diagnosed...

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PMID: 20924129
DOI: 10.1158/1078-0432.ccr-10-1491

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