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Clinical implications of genetic testing in familial intermediate and late-onset colorectal cancer.

Human genetics - 1 Dec 2022

Djursby Malene, Hansen Thomas van Overeem, Wadt Karin A W, Madsen Majbritt Busk, Berchtold Lukas Adrian, Lautrup Charlotte Kvist, Markholt Sara, Jensen Uffe Birk, Krogh Lotte Nylandsted, Lundsgaard Malene, Gerdes Anne Marie, Nilbert Mef, Therkildsen Christina

Abstract excerpt

The genetic background of familial, late-onset colorectal cancer (CRC) (i.e., onset > age 50 years) has not been studied as thoroughly as other subgroups of familial CRC, and the proportion of families with a germline genetic predisposition to CRC remains to be defined. To define the contribution of known or suggested CRC predisposition genes to familial late-onset CRC, we analyzed 32 well-established or...

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PMID: 35904628
DOI: 10.1007/s00439-022-02470-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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