Article
Frequencies of mtDNA mutations in primary tissues of colorectal adenopolyps.
Frontiers in bioscience (Elite edition) - 1 Jun 2013
Adams Gregory, Mehrabi Sharifeh, Vatcharapijarn Yupha, Iyamu Osatohamwen I, Akwe Joyce A, Grizzle William E, Yao Xuebiao, Aikhionbare Felix O
Abstract excerpt
To investigate the potential role of mtDNA alterations during the onset of colorectal cancer, the occurrence of mtDNA variants in colorectal adenomatous (Tubular, Tubulovillous, and Villous) polyps, were studied. High resolution endonucleases and PCR-based sequence were applied to examine mtDNA variants in the ND and ATPase genes of 64 primary tissues of colorectal adeno-polyps and their matched normal controls....
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