Population and family studies of HLA-DR4 by use of oligonucleotide typing.

doi:10.1111/j.1399-0039.1992.tb01946.x

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Article

Population and family studies of HLA-DR4 by use of oligonucleotide typing.

Tissue antigens - 1 May 1992

Reed E, Lupu F, McManus P, Seigle R, Suciu-Foca N

Abstract excerpt

Using PCR and DR4 group-specific primers and SSO's we have examined DRB1*04 nucleotide polymorphisms in a population of 123 DR4-positive individuals (86 NAC, 27 Hispanics and 10 African Americans) from New York carrying a total of 134 DR4 haplotypes. We found that the distribution of DRB1*04 alleles on DR4 haplotypes differs in these three ethnic groups. In this relatively small population, certain alleles such...

Topics

Amino Acid Sequence
Base Sequence
Black People
Disease Susceptibility
Ethnicity
Gene Frequency
Genetic Predisposition to Disease
HLA-DR Antigens
HLA-DR4 Antigen
HLA-DRB1 Chains
Hispanic or Latino

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class II

Humans

Molecular Sequence Data

New York City

Nucleic Acid Hybridization

Oligonucleotide Probes

Polymerase Chain Reaction

Source

Open in PubMed

Identifiers

PMID: 1412412
DOI: 10.1111/j.1399-0039.1992.tb01946.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1412412-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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