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Article

Pharmacological chaperones: a new twist on receptor folding.

Trends in pharmacological sciences - 1 Dec 2000

Morello J P, Petäjä-Repo U E, Bichet D G, Bouvier M

Abstract excerpt

Protein misfolding is at the root of several genetic human diseases. These diseases do not stem from mutations within the active domain of the proteins, but from mutations that disrupt their three-dimensional conformation, which leads to their intracellular retention by the quality control apparatus of the cell. Facilitating the escape of the mutant proteins from the quality control system by lowering the...

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PMID: 11121835
DOI: 10.1016/s0165-6147(00)01575-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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