Chemical chaperones assist intracellular folding to buffer mutational variations.

doi:10.1038/nchembio.768

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Article

Chemical chaperones assist intracellular folding to buffer mutational variations.

Nature chemical biology - 15 Jan 2012

Bandyopadhyay Anannya, Saxena Kanika, Kasturia Neha, Dalal Vijit, Bhatt Niraj, Rajkumar Asher, Maity Shuvadeep, Sengupta Shantanu, Chakraborty Kausik

Abstract excerpt

Hidden genetic variations have the potential to lead to the evolution of new traits. Molecular chaperones, which assist protein folding, may conceal genetic variations in protein-coding regions. Here we investigate whether the chemical milieu of cells has the potential to alleviate intracellular protein folding, a possibility that could implicate osmolytes in concealing genetic variations. We found that the model...

Topics

Kinetics
Maltose-Binding Proteins
Methylamines
Mutation
Polymerase Chain Reaction
Protein Folding

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Identifiers

PMID: 22246401
DOI: 10.1038/nchembio.768
PMCID: PMC3527004

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