Beyond the signal sequence: protein routing in health and disease.

Abstract excerpt

Receptors, hormones, enzymes, ion channels, and structural components of the cell are created by the act of protein synthesis. Synthesis alone is insufficient for proper function, of course; for a cell to operate effectively, its components must be correctly compartmentalized. The mechanism by which proteins maintain the fidelity of localization warrants attention in light of the large number of different...

Topics

• Animals
• Disease
• Endoplasmic Reticulum
• Golgi Apparatus
• Humans
• Mitochondria
• Molecular Chaperones
• Mutation
• Nervous System Diseases
• Protein Conformation
• Protein Sorting Signals