Article
Nucleotide sugar transporters of the Golgi apparatus: from basic science to diseases.
Accounts of chemical research - 1 Nov 2006
Caffaro Carolina E, Hirschberg Carlos B
Abstract excerpt
Approximately 80% of secreted and membrane proteins (40% of all proteins) of eukaryotes become covalently linked to sugars in the lumen of the Golgi apparatus, a cellular organelle that is part of the secretory system of all eukaryotes. The sugar donors are mostly nucleoside diphosphate sugars (nucleotide sugars) and must be translocated from the cytosol, their site of synthesis, across the Golgi apparatus...
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