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Article

Targeting trafficking as a therapeutic avenue for misfolded GPCRs leading to endocrine diseases.

Frontiers in endocrinology - 1 Jan 2022

Ulloa-Aguirre Alfredo, Zariñán Teresa, Gutiérrez-Sagal Rubén, Tao Ya-Xiong

Abstract excerpt

G protein-coupled receptors (GPCRs) are plasma membrane proteins associated with an array of functions. Mutations in these receptors lead to a number of genetic diseases, including diseases involving the endocrine system. A particular subset of loss-of-function mutant GPCRs are misfolded receptors unable to traffic to their site of function (i.e. the cell surface plasma membrane). Endocrine disorders in humans...

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Identifiers

PMID: 36093106
DOI: 10.3389/fendo.2022.934685
PMCID: PMC9452723

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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