Article
The roles of amino acid residues at positions 43 and 45 in microsomal contents and enzymatic functions of rat CYP2D1 and CYP2D2.
Biochemical and biophysical research communications - 12 Nov 2004
Narimatsu Shizuo, Imoto Kazuo, Isobe Takashi, Kiryu Kimio, Naito Shinsaku, Hichiya Hiroyuki, Funae Yoshihiko, Hanioka Nobumitsu, Yamamoto Shigeo
Abstract excerpt
The effects of the substitution of amino acid residues at positions 43 and 45 of rat CYP2D1 and CYP2D2 on their microsomal contents and enzymatic functions were examined. The substitution of Val-45 of CYP2D1 by glycine decreased the microsomal content, whereas the substitution of Gly-45 of CYP2D2 by valine increased. The substitution of Leu-43 of CYP2D2 by tryptophan also increased the microsomal protein content....
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