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Article

Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jul 2010

Huang Qingbiao, Szklarz Grazyna D

Abstract excerpt

Human CYP1A2 is an important drug-metabolizing enzyme, similar in sequence to CYP1A1 but with distinct substrate specificity. We have previously shown that residue 382 affected CYP1A1 and CYP1A2 specificities with alkoxyresorufins. To determine whether this residue is also important for the metabolism of other substrates, we have investigated phenacetin oxidation by single (T124S, T223N, V227G, N312L, and L382V)...

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Identifiers

PMID: 20335269
DOI: 10.1124/dmd.109.030767
PMCID: PMC2908983

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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