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Article

Quantitation of human cytochrome P450 2D6 protein with immunoblot and mass spectrometry analysis.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2009

Yu Ai-Ming, Qu Jun, Felmlee Melanie A, Cao Jin, Jiang Xi-Ling

Abstract excerpt

Accurate quantification of cytochrome P450 (P450) protein contents is essential for reliable assessment of drug safety, including the prediction of in vivo clearance from in vitro metabolism data, which may be hampered by the use of uncharacterized standards and existence of unknown allelic isozymes. Therefore, this study aimed to delineate the variability in absolute quantification of polymorphic CYP2D6...

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Identifiers

PMID: 18832475
DOI: 10.1124/dmd.108.024166
PMCID: PMC2683657

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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