Article
Identification and characterization of <i>Saccharomyces cerevisiae EXO1</i> , a gene encoding an exonuclease that interacts with MSH2
8 Jul 1997
Abstract excerpt
A two-hybrid screen was used to identify Saccharomyces cerevisiae genes encoding proteins that interact with MSH2. One gene was found to encode a homologue of Schizosaccharomyces pombe EXO1, a double-stranded DNA-specific 5'-3' exonuclease. S. cerevisiae EXO1 interacted with both S. cerevisiae and human MSH2 in two-hybrid and coimmunoprecipitation experiments. exo1 mutants showed a mutator phenotype, and...