Article
Ergosterol gene expression in wild-type and ergosterol-deficient mutants of Candida albicans.
Medical mycology - 1 Aug 2004
Pierson C A, Eckstein J, Barbuch R, Bard M
Abstract excerpt
The ergosterol pathway is the major target of the azole antifungals. We have developed a panel of five viable ergosterol biosynthetic mutants (erg2, erg3, erg6, erg11 and erg24) and have performed Northern analyses to study transcriptional regulation using probes to four ergosterol biosynthetic genes (ERG2, ERG7, ERG11 and ERG25), as well as probes to two additional genes encoding ergosterol cytochrome coenzymes...
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